Differin

Pros

• Highly effective for cystic and hormonal acne for many users
• Provides long-term skin texture improvements and clarity
• Accessible over-the-counter alternative to prescription-strength retinoids
• Can be used alongside soothing products like hypochlorous acid spray

Cons

• High potential for severe irritation and destroying the skin barrier
• The 'purging' phase can cause temporary worsening of acne and texture
• May be ineffective for some users even after years of consistent use
• Can cause stinging, itching, and extreme dryness if overused

Caveats

• Users strongly recommend starting slowly (e.g., 2 nights a week) rather than jumping into nightly use
• Avoid using other exfoliating actives (like benzoyl peroxide or acids) simultaneously during the initial adjustment period
• If results are not seen after long-term use (e.g., 5 years), users often suggest 'leveling up' to tretinoin via a dermatologist

Best for

• Individuals with persistent cystic or hormonal acne
• Users looking for a long-term acne treatment who can tolerate an initial adjustment period
• Those seeking to clear closed comedones

Avoid if

• You have an already compromised or highly sensitive skin barrier
• You are unwilling to simplify your routine by removing other harsh exfoliants
• You expect immediate results without a potential 'purging' phase